Transcriptomic analysis of adipose tissue reveals adipogenesis is modulated by the degree of weight loss in patients with obesity

We demonstrated that successful lifestyle interventions and bariatric surgery share the modulation of the Adipogenesis pathway (WP236). Leptin expression was positively correlated with weight loss, only up to a 10 % weight loss, suggesting a possible involvement of its dysregulation in explaining individual propensity to weight regain and potentially indicating who requires a targeted intervention. We also identify an interesting relationship between RBL2 expression and weight loss that requires further investigation.