Precursor-Directed Biosynthesis of Phenylpyrrole Analogues in <i>Myrothecium verrucaria</i>
Supplementation of <i>p</i>-aminobenzoic acid and its derivatives into the culture medium of <i>Myrothecium verrucaria</i> HPU-ZMN, a fungus isolated from the Yellow River wetland, resulted in the production of 21 novel phenylpyrrole derivatives designated as myropherroles A-U (<b>1</b>-<b>21</b>). Structural elucidation of these compounds was achieved through a comprehensive analysis of NMR and HRESIMS data. Notably, the myropherroles exhibit more diverse structures of the pyrrole compared to naturally occurring phenylpyrrole derivatives. Compound <b>2</b> displayed an acetylcholinesterase (AChE) inhibitory effect with an IC<sub>50</sub> value of 0.9 μM.
Authors
- Dehai Li (ORCID: https://orcid.org/0000-0002-7191-2002)
- Zhenhui Wang (ORCID: https://orcid.org/0000-0001-6979-840X)
- Miaomiao Chai
- Xiaomin Zhang (ORCID: https://orcid.org/0000-0003-4898-4152)
- Bing Wang (ORCID: https://orcid.org/0000-0003-1632-3114)
- Zhenzhen Zhang (ORCID: https://orcid.org/0000-0002-7605-8730)
- Wei Li (ORCID: https://orcid.org/0000-0003-4136-4938)
- Xueqian He
Institutions
- Jiaozuo University (CN)
- Henan Polytechnic University (CN)
- Indiana University School of Medicine
- Ocean University of China (CN)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1021/acs.jnatprod.5c00238
- Citations
- 1
- Primary Topic
- Plant tissue culture and regeneration
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Henan Polytechnic University
- Natural Science Foundation of Henan Province
- Science and Technology Department of Henan Province