Advanced glycation end-product intake predicts insulin resistance in a sex-dependent fashion
Dietary AGEs exert a sex-dependent effect on insulin resistance as their intake is associated with and able to predict HOMA-IR in females but not males. This suggests that females may be more susceptible to the deleterious impact of these glycotoxins on insulin sensitivity. Nevertheless, considering this study not involving a nutritional intervention to directly elucidate whether the effect of AGEs on insulin resistance is sex-dependent, further studies are warranted to confirm the present findings.
Authors
- Domenico Sergi (ORCID: https://orcid.org/0000-0002-3001-410X)
- Juana María Sanz (ORCID: https://orcid.org/0000-0003-3372-2758)
- Giovanni Zuliani (ORCID: https://orcid.org/0000-0003-0969-3184)
- Riccardo Spaggiari (ORCID: https://orcid.org/0000-0001-6069-7514)
- Angelina Passaro (ORCID: https://orcid.org/0000-0001-8462-7000)
- Fabiola Castaldo
- Sharon Angelini
Institutions
- University of Ferrara (IT)
Publication Details
- Journal
- European Journal of Nutrition
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1007/s00394-025-03672-3
- Citations
- 1
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- Università degli Studi di Padova
- Università degli Studi di Ferrara
- Università degli Studi di Udine
- European Regional Development Fund