Extensive modulation of the circulating blood proteome by hormonal contraceptive use across two population studies
HCU is the dominant factor reshaping the high-abundant circulating blood proteome in two population studies. Given the high prevalence of HCU among young women, it is essential to account for this treatment in human proteome studies to avoid misinterpreting its impact as sex- or age-related effects. Although we did not investigate the influence of HCU-induced proteomic changes on human health, our data suggest that future studies on this topic are warranted.
Authors
- Vinicius Verri Hernandes (ORCID: https://orcid.org/0000-0002-3057-6460)
- Nikola Đorđević (ORCID: https://orcid.org/0000-0002-2564-5636)
- Alessandro De Grandi (ORCID: https://orcid.org/0000-0003-1522-0586)
- Kathrin Textoris‐Taube (ORCID: https://orcid.org/0000-0002-1224-8236)
- Essi Marjatta Hantikainen (ORCID: https://orcid.org/0000-0002-4155-2894)
- Orr Shomroni (ORCID: https://orcid.org/0000-0002-8009-2392)
- Vadim Farztdinov (ORCID: https://orcid.org/0000-0003-4441-2552)
- Francisco S. Domingues (ORCID: https://orcid.org/0000-0003-4567-4562)
- Fatma Amari
- Michael Mülleder (ORCID: https://orcid.org/0000-0001-9792-3861)
- Peter Paul Pramstaller (ORCID: https://orcid.org/0000-0002-9831-8302)
- Markus Ralser (ORCID: https://orcid.org/0000-0001-9535-7413)
- Florian Kurth (ORCID: https://orcid.org/0000-0002-3807-473X)
- Ilja Demuth (ORCID: https://orcid.org/0000-0002-4340-2523)
- Clemens Dierks (ORCID: https://orcid.org/0000-0002-4560-8939)
- Johannes Rainer (ORCID: https://orcid.org/0000-0002-6977-7147)
- Vivien Bahr (ORCID: https://orcid.org/0009-0000-9545-3376)
- Holger Schmid (ORCID: https://orcid.org/0009-0008-7695-937X)
Institutions
- University of Vienna (AT)
- Eurac Research (IT)
- Centre for Human Genetics (GB)
- Nuffield Orthopaedic Centre (GB)
- Humboldt-Universität zu Berlin (DE)
- University of Oxford (GB)
- Ospedale di Bolzano (IT)
- Institute for Biomedicine (IT)
- German Center for Lung Research (DE)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Max Planck Institute for Molecular Genetics (DE)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1038/s43856-025-00856-0
- Citations
- 7
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 5.29
Funders
- Wellcome Trust
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
- Provincia autonoma di Bolzano - Alto Adige
- European Regional Development Fund