Genomic and Single-Cell Analyses Characterize Patient-Derived Tumor Organoids to Enable Personalized Therapy for Head and Neck Squamous Cell Carcinoma
Profiling of patient-derived organoids uncovers intertumoral heterogeneity and a hybrid epithelial-mesenchymal transition program conferring cisplatin resistance and highlights amphiregulin as a regulator of cellular plasticity and potential therapeutic target for HNSCC treatment.
Authors
- De‐Chen Lin (ORCID: https://orcid.org/0000-0002-1951-367X)
- Yueyuan Zheng (ORCID: https://orcid.org/0000-0002-5692-8903)
- Chehyun Nam (ORCID: https://orcid.org/0000-0001-8604-2313)
- Yoon Woo Koh (ORCID: https://orcid.org/0000-0002-9734-1682)
- Hua Zhao (ORCID: https://orcid.org/0000-0001-7148-547X)
- Su‐Jin Shin (ORCID: https://orcid.org/0000-0001-9114-8438)
- Jung Hyun Um
- Young Min Park (ORCID: https://orcid.org/0000-0002-7593-8461)
- Qiong Mao
Institutions
- University of Southern California (US)
- Sun Yat-sen University (CN)
- Yonsei University (KR)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- USC Norris Comprehensive Cancer Center (US)
- Gangnam Severance Hospital (KR)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1158/0008-5472.can-24-2850
- Citations
- 7
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 6.55
Funders
- National Research Foundation of Korea
- National Institute of Dental and Craniofacial Research
- Division of Diabetes, Endocrinology, and Metabolic Diseases