A Copper Paradodecatungstate-B Compound Decorated by Glycine Ligand: Synthesis, Structure, and Anticancer Activities

In this study, a polyoxometalate-based inorganic-organic hybrid material, Na₄[Cu₄(Gly)₂(HGly)₂(H₄W₁₂O₄₂)]Cl₂·20H₂O (<b>1</b>) (Gly = glycine), was synthesized via a self-assembly approach by incorporating copper ions and glycine into the paradodecatungstate anion [H₄W₁₂O₄₂]^8-. The structure and properties of compound <b>1</b> were systematically characterized using single crystal X-ray diffraction, elemental analysis, powder X-ray diffraction, FTIR, Raman spectroscopy, cyclic voltammetry (CV), and UV-vis spectroscopy. Additionally, its anticancer activity was evaluated in vitro against human liver cancer cells (HepG2) and human renal epithelial cells (HEK293T) using the MTT assay, yielding an IC₅₀ value of 36.232 ± 0.41 μM. The findings demonstrate that compound <b>1</b> effectively inhibits the proliferation of liver cancer cells, highlighting its potential as a candidate for polyoxotungstate (POT)-based anticancer drug development.