Effect of propinox and pinaverium bromide on ex vivo colonic motor patterns and their synergistic effect with hyoscine butyl bromide
The pharmacological profile obtained in this study was consistent with an L-type calcium channel blocker for both pinaverium bromide and propinox, with an unlikely or a weak antimuscarinic effect for the latter. When combined with the antimuscarinic agent HBB, both pinaverium bromide and propinox showed a synergistic inhibition of contractile responses. This finding could have clinical implications, suggesting a combination treatment approach for greater therapeutic benefits.
Authors
- Carolina Malagelada (ORCID: https://orcid.org/0000-0001-7097-1492)
- Marcel Jiménez (ORCID: https://orcid.org/0000-0002-6602-7332)
- Sara Traserra
- Luis G. Alcalá‐González (ORCID: https://orcid.org/0000-0003-3247-1539)
- Robert Lange (ORCID: https://orcid.org/0000-0002-9500-1238)
- Terence Appelqvist
- Stefania Landolfi (ORCID: https://orcid.org/0000-0002-1059-635X)
- Maura Corsetti (ORCID: https://orcid.org/0000-0003-2957-4684)
- Claudia Barber (ORCID: https://orcid.org/0000-0003-4711-2731)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Sanofi (France) (FR)
- NIHR Nottingham Digestive Diseases Biomedical Research Unit (GB)
- Vall d'Hebron Hospital Universitari (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Sanofi (Germany) (DE)
- Nottingham Biomedical Research Centre (GB)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fphar.2025.1491123
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sanofi