Genetic association between gene expression profiles in oligodendrocyte precursor cells and psychiatric disorders
The present results highlight the previously underappreciated role of OPCs in psychiatric disorders, suggesting that OPC-involved synaptic interactions may contribute to the pathophysiology of SCZ. This work underscores the importance of considering OPCs as active players in neural network dysfunction, with potential implications for future therapeutic strategies.
Authors
- Hiroki Kimura (ORCID: https://orcid.org/0000-0002-0610-7904)
- Masashi Ikeda (ORCID: https://orcid.org/0000-0001-6237-2449)
- Reon Kondo
Institutions
- Nagoya University (JP)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-04-22
- DOI
- https://doi.org/10.3389/fpsyt.2025.1566155
- Citations
- 3
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology
- Eisai
- Meiji Seika Pharma
- Otsuka Pharmaceutical
- H. Lundbeck A/S
- Japan Society for the Promotion of Science