Brief Report: Exploratory Substudy of a Phase 2 Trial to Evaluate the Pharmacokinetic Effect of Once-Monthly Islatravir on Long-Acting Reversible Contraceptives

Coadministration with once-monthly islatravir does not seem to affect exposure to LARCs in people at low risk of HIV-1 infection. Owing to the exploratory nature of this substudy, prospective studies are needed to verify these findings.

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Publication Details

Journal
JAIDS Journal of Acquired Immune Deficiency Syndromes
Published
2025-04-22
DOI
https://doi.org/10.1097/qai.0000000000003678
Primary Topic
Reproductive Health and Contraception
Type
article
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article

Brief Report: Exploratory Substudy of a Phase 2 Trial to Evaluate the Pharmacokinetic Effect of Once-Monthly Islatravir on Long-Acting Reversible Contraceptives

Katherine Nedrow, Brenda Homony, Rebeca M. Plank, Prachi Wickremasingha et al.
JAIDS Journal of Acquired Immune Deficiency Syndromes
Reproductive Health and Contraception
article

Brief Report: Exploratory Substudy of a Phase 2 Trial to Evaluate the Pharmacokinetic Effect of Once-Monthly Islatravir on Long-Acting Reversible Contraceptives

Katherine Nedrow, Brenda Homony, Rebeca M. Plank, Prachi Wickremasingha, Ryan C. Vargo, Michael Robertson, Munjal Patel, Michelle M Pham
article en

Abstract

Coadministration with once-monthly islatravir does not seem to affect exposure to LARCs in people at low risk of HIV-1 infection. Owing to the exploratory nature of this substudy, prospective studies are needed to verify these findings.

JAIDS Journal of Acquired Immune Deficiency SyndromesVol. 99(4)
Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
Good health and well-being
Openalex Percentile: Top 88%
Reproductive Health and Contraception
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