MicroRNA-665 and its potential role in drug response and survival outcomes in multiple myeloma: a preliminary study
Our preliminary findings suggest that miR-665 could potentially serve as a non-invasive tool for predicting drug resistance and guiding treatment decisions in MM. These findings also highlight the potential utility of miRNAs in liquid biopsies as a predictive tool of drug response in MM and could pave the way for personalized treatment strategies, improving patient outcomes. Future research is needed to validate these results in larger cohorts and explore the underlying mechanisms of miR-665 in MM pathogenesis and drug resistance.
Authors
- M. Helena Vasconcelos (ORCID: https://orcid.org/0000-0002-7801-4643)
- Rui Bergantim (ORCID: https://orcid.org/0000-0002-7811-9509)
- Rune Matthiesen (ORCID: https://orcid.org/0000-0002-6353-2616)
- Diana Aguiar de Sousa (ORCID: https://orcid.org/0000-0002-6702-7924)
- Sara Peixoto da Silva (ORCID: https://orcid.org/0000-0003-2030-6368)
- Vanessa Carla Monteiro Pinto (ORCID: https://orcid.org/0000-0003-3604-7786)
- Joana Pereira (ORCID: https://orcid.org/0000-0002-9793-9764)
- Fernanda Trigo
- José E. Guimarães
Institutions
- Universidade do Porto (PT)
- Universidade Católica Portuguesa (PT)
- Hospital de São João (PT)
- Cooperativa de Ensino Superior Politécnico e Universitário (PT)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-04
- DOI
- https://doi.org/10.3389/fphar.2025.1465814
- Citations
- 3
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.31
Funders
- Fundação para a Ciência e a Tecnologia