HR‐MS Analysis of the Covalent Binding of Edaravone to 5‐Formylpyrimidine Bases and a DNA Oligonucleotide Containing a 5‐Formylcytidine Residue
These observations raise implications for an epigenetic contribution to the mechanism of action of EDA. The biological implications of our in vitro results are discussed, notably in the frame of neurodegenerative diseases and cancers.
Authors
- Laurence Goossens (ORCID: https://orcid.org/0000-0001-6961-9491)
- Jean‐François Goossens
- Romain Regnault (ORCID: https://orcid.org/0000-0001-9040-9245)
- Xavier Thuru (ORCID: https://orcid.org/0000-0002-0998-4160)
- Mostafa Kouach (ORCID: https://orcid.org/0000-0002-2034-800X)
- Christian Bailly (ORCID: https://orcid.org/0000-0002-2973-9357)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Lille (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Onco Lille (FR)
Publication Details
- Journal
- Rapid Communications in Mass Spectrometry
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1002/rcm.10050
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ligue Contre le Cancer