ETV4/ALYREF-mediated glycolytic metabolism through PKM2 enhances resistance to ferroptosis and promotes the development of intrahepatic cholangiocarcinoma
ETV4 promotes ICC development and ferroptosis resistance by facilitating glycolytic metabolism, and regulating PKM2 transcription by directly binding to the PKM2 promoter. Additionally, it mediates m5C-dependent PKM2 stabilization by directly binding to ALYREF. This study identified a new potential therapeutic target for ICC.
Authors
- Zhongzhi Ma
- Changjun Liu (ORCID: https://orcid.org/0000-0001-9918-1638)
- Xianhai Mao (ORCID: https://orcid.org/0000-0002-7319-6943)
- Hannah Yong Wen (ORCID: https://orcid.org/0000-0001-6794-5234)
- Xiaohui Wang (ORCID: https://orcid.org/0000-0001-8355-3871)
- Wenbin Duan
Institutions
- Central South University (CN)
- Hunan Cancer Hospital (CN)
Publication Details
- Journal
- Cancer & Metabolism
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s40170-025-00387-1
- Citations
- 7
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 14.04
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province