The impact of an RNA-binding protein group on regulating the RSPO-LGR4/5-ZNRF3/RNF43 module and the immune microenvironment in hepatocellular carcinoma
In our study, we identified core HPARBPs that might contribute to HCC progression by binding to RNAs in the RSPO-LGR4/5-ZNRF3/RNF43 module. Changes in the expression of HPARBPs affect the HCC immune microenvironment. Our findings offer novel insights into the regulatory network of Wnt pathway-related RBPs and their potential clinical value in HCC.
Authors
- Yiqiang Chen (ORCID: https://orcid.org/0000-0002-8407-0780)
- Shuting Huang (ORCID: https://orcid.org/0000-0002-1526-8048)
- Zhengyao Xie (ORCID: https://orcid.org/0000-0002-5380-8316)
- Zhijun Dai (ORCID: https://orcid.org/0000-0001-5209-8626)
- Jingjing Li (ORCID: https://orcid.org/0000-0003-2751-9753)
- Siyuan Liu (ORCID: https://orcid.org/0000-0002-3770-2220)
- Jie Shen (ORCID: https://orcid.org/0000-0002-0241-9847)
- Ziyao Liu (ORCID: https://orcid.org/0000-0003-4060-0839)
Institutions
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1186/s12885-025-13874-x
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Peking University
- Nanjing Drum Tower Hospital