Izalontamab (SI-B001), a Novel EGFRxHER3 Bispecific Antibody in Patients with Locally Advanced or Metastatic Epithelial Tumor: Results from First-in-Human Phase I/Ib Study
Izalontamab was well tolerated and demonstrated preliminary antitumor activity in patients with locally advanced or metastatic epithelial tumors, supporting it as a promising therapeutic candidate for combination therapies, with a phase III study currently underway.
Authors
- Hongyun Zhao (ORCID: https://orcid.org/0000-0002-1251-3888)
- Yuanyuan Zhao (ORCID: https://orcid.org/0000-0002-7148-7608)
- Jinhui Xue (ORCID: https://orcid.org/0000-0002-9791-2940)
- Wei Hong (ORCID: https://orcid.org/0000-0002-8359-9703)
- Shaodong Hong (ORCID: https://orcid.org/0000-0002-5632-6857)
- Yunpeng Yang (ORCID: https://orcid.org/0000-0001-6987-2219)
- Yan Huang (ORCID: https://orcid.org/0000-0002-1789-5088)
- Li Zhang (ORCID: https://orcid.org/0000-0003-0595-0761)
- Yuxiang Ma (ORCID: https://orcid.org/0000-0003-1173-8441)
- Sa Xiao (ORCID: https://orcid.org/0009-0008-3502-5319)
- Wenfeng Fang (ORCID: https://orcid.org/0000-0002-6440-8246)
- Yang Zhang (ORCID: https://orcid.org/0009-0008-6945-834X)
- Hai Zhu (ORCID: https://orcid.org/0009-0003-1516-0998)
- Yongsheng Wang (ORCID: https://orcid.org/0009-0007-6865-4325)
- Qianwen Liu (ORCID: https://orcid.org/0000-0003-2001-4023)
- Yi Zhu (ORCID: https://orcid.org/0009-0005-1172-093X)
Institutions
- Sun Yat-sen University (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Zhejiang Cancer Hospital (CN)
- Buchang Pharma (China) (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Sun Yat-sen University Cancer Center (CN)
- University of Chinese Academy of Sciences (CN)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0206
- Citations
- 7
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 7.32
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Sun Yat-sen University Cancer Center