Straightforward Access to 4-Sulfenylated Isocoumarins via Sulfoxides/MOMCl-Enabled Regioselective Cleavage and Reconfiguration of C–S Bonds
The combination of sulfoxides with MOMCl has been found for the first time to mediate electrophilic cyclization and install a variety of sulfenyl groups onto isocoumarin skeletons via regioselective cleavage and reconfiguration of C-S bonds. Notably, MOMCl, a mild and readily available alkyl chloride, was indispensable and played a significant role as an activator under neutral conditions in this transformation, thus expanding the scope of acid-labile substrates.
Authors
- Yongjun Zheng (ORCID: https://orcid.org/0000-0002-2359-1099)
- Haoyuan Fan (ORCID: https://orcid.org/0009-0005-2924-2948)
- Wei Wang
- Yong Zhang (ORCID: https://orcid.org/0000-0002-7666-6242)
- Haixia Zheng
- Shixun Cao (ORCID: https://orcid.org/0000-0002-3915-2621)
- Yunfei Du (ORCID: https://orcid.org/0000-0002-0213-2854)
- Feng Hua (ORCID: https://orcid.org/0000-0002-8098-9095)
- Linlin Xing (ORCID: https://orcid.org/0000-0002-7704-6942)
Institutions
- Tianjin University (CN)
- Peking University (CN)
- Center for Interdisciplinary Studies (IN)
- Anyang Institute of Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1021/acs.joc.5c00287
- Citations
- 2
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.87
Funders
- Natural Science Foundation of Henan Province
- Key Scientific Research Project of Colleges and Universities in Henan Province