Social factors, health policy, and environment: implications for cardiovascular disease across the globe
Cardiovascular disease (CVD) is the leading cause of deaths worldwide, with 80% occurring in low- and middle-income countries. These countries are characterized by rapid urbanization, poorly funded health systems, poor access to prevention and treatment strategies, and increasing age and a higher prevalence of chronic disease. Rapid urbanization has contributed to the significant environmental and societal changes affecting daily life habits and cardiovascular health. There is growing awareness that environmental and social exposures and policies can influence CVD directly or through behavioural risk factors. However, much of this knowledge comes from studies in high-income countries and is applied to low- and middle-income countries without evidence to indicate this is appropriate. This state-of-the-art review will present and synthesize key findings from the Prospective Urban Rural Epidemiology study and related studies that have aimed to understand the environmental, social, and policy determinants of cardiovascular health in countries across varying levels of economic development through an urban/rural lens. Emerging from these findings are future policy and research recommendations to accelerate the reduction of the global burden of CVD.
Authors
- Clara K Chow (ORCID: https://orcid.org/0000-0003-4693-0038)
- Adrianna Murphy (ORCID: https://orcid.org/0000-0003-4065-6744)
- Salim Yusuf (ORCID: https://orcid.org/0000-0003-4776-5601)
- Martin McKee (ORCID: https://orcid.org/0000-0002-0121-9683)
- Scott Alexander Lear (ORCID: https://orcid.org/0000-0001-7614-755X)
- Annika Rosengren (ORCID: https://orcid.org/0000-0002-5409-6605)
- Sumathy Rangarajan (ORCID: https://orcid.org/0000-0003-2420-5986)
- Michael D Brauer (ORCID: https://orcid.org/0000-0002-9103-9343)
- Marjan Walli-Attaei (ORCID: https://orcid.org/0000-0003-4222-3205)
- Perry Hystad (ORCID: https://orcid.org/0000-0002-9454-4986)
- Blake Byron Walker
Institutions
- The University of Sydney (AU)
- Oregon State University (US)
- University of British Columbia (CA)
- Simon Fraser University (CA)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Population Health Research Institute (CA)
- Westmead Hospital (AU)
- University of Oxford (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Faculty of Public Health (GB)
- Hamilton Health Sciences (CA)
- University of Gothenburg (SE)
- McMaster University (CA)
Publication Details
- Journal
- European Heart Journal
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1093/eurheartj/ehaf212
- Citations
- 14
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 16.80
Funders
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Sanofi
- Heart and Stroke Foundation of Canada
- Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)
- Hamilton Health Sciences
- Dairy Farmers of Canada
- Public Health Agency of Canada
- International Development Research Centre
- Ontario Ministry of Health and Long-Term Care
- National Research Foundation
- Indian Council of Medical Research
- Public Health Agency
- King Saud University
- Saudi Heart Association
- AFA Försäkring
- Ministério da Ciência, Tecnologia e Inovação
- Vetenskapsrådet
- Universiti Kebangsaan Malaysia
- Universiti Teknologi MARA
- North-West University
- Universidad de La Frontera
- Uniwersytet Medyczny im. Piastów Slaskich we Wroclawiu
- Servier
- Independent University, Bangladesh
- Canadian Institutes of Health Research
- Medical Research Council
- Philippine Council for Health Research and Development
- Faculty of Community and Health Sciences, University of the Western Cape