A Gradual Positive Bias in Chloride Measurements with a Major Automated Chemistry Platform
The use of peer targets for quality control and proficiency testing concealed the detection of a gradual drift in chloride measurements in our laboratory. Analysis of aggregate patient data using ICD-10 codes represents a powerful tool for laboratories when assay performance is questioned. These findings highlight the need for vigilant monitoring of assay drift even for routine analytes to avert potential impact on patient care.
Authors
- Kwaku Twum (ORCID: https://orcid.org/0000-0001-5390-0609)
- Steven W. Cotten (ORCID: https://orcid.org/0000-0003-1431-9883)
- Ruhan Wei (ORCID: https://orcid.org/0000-0001-8340-8260)
- Nichole L Korpi-Steiner (ORCID: https://orcid.org/0009-0007-7924-599X)
Institutions
- University of North Carolina at Chapel Hill (US)
- Duke Medical Center (US)
Publication Details
- Journal
- The Journal of Applied Laboratory Medicine
- Published
- 2025-04-22
- DOI
- https://doi.org/10.1093/jalm/jfaf046
- Primary Topic
- Renal function and acid-base balance
- Type
- article
- Field-Weighted Citation Impact
- 0.00