Complement Activation is More Pronounced in the Kidneys of Critically Ill Patients With COVID-19 Than in Those With Bacterial Sepsis
There was marked tubulointerstitial complement deposition in the kidneys of patients with COVID-19, particularly in the peritubular capillaries, with activation via the alternative pathway. Thus, alternative complement pathway inhibition might be a possible treatment option for patients with COVID-19 AKI.
Authors
- Marius C. van den Heuvel (ORCID: https://orcid.org/0000-0001-6985-7107)
- Meint Volbeda (ORCID: https://orcid.org/0000-0001-7641-1330)
- Firas Farisi Alkaff (ORCID: https://orcid.org/0000-0002-5628-1345)
- Stefan P. Berger (ORCID: https://orcid.org/0000-0003-2228-4676)
- Jill Moser (ORCID: https://orcid.org/0000-0002-9614-2577)
- Matijs van Meurs (ORCID: https://orcid.org/0000-0002-7745-2772)
- Grietje G Talen
- Jacob van den Born
- Mohamed R. Daha
Institutions
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- Universitas Airlangga (ID)
- Leiden University Medical Center (NL)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.ekir.2025.04.027
- Primary Topic
- COVID-19 Impact on Reproduction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universitas Airlangga