Distinctive features of blood- and ascitic fluid-derived extracellular vesicles in ovarian cancer patients
The results highlight a clear difference between the two biological fluids, suggesting that tumor selectively releases specific EVs populations in serum or ascites. In this context, it seems that ascites-derived EVs play a major role in modulating EMT and metastatic cascade, which is a key feature of OC.
Authors
- Francesca Gorini (ORCID: https://orcid.org/0000-0002-1520-6488)
- Patrizia Hrelia (ORCID: https://orcid.org/0000-0002-8415-3711)
- Antonio De Leo (ORCID: https://orcid.org/0000-0002-3761-5135)
- Anna Myriam Perrone (ORCID: https://orcid.org/0000-0003-3140-4772)
- Sabrina Angelini (ORCID: https://orcid.org/0000-0002-1609-0421)
- Stella Di Costanzo (ORCID: https://orcid.org/0000-0003-2877-0261)
- Dario de Biase (ORCID: https://orcid.org/0000-0002-0609-8817)
- Mattia Melloni (ORCID: https://orcid.org/0000-0003-3987-7267)
- Ivan Vannini (ORCID: https://orcid.org/0000-0002-9279-1801)
- Riccardo Di Corato (ORCID: https://orcid.org/0000-0002-7173-6176)
- Camelia Alexandra Coadǎ (ORCID: https://orcid.org/0000-0001-8362-6639)
- Giulia Dondi (ORCID: https://orcid.org/0000-0001-8393-1799)
- Flora Guerra (ORCID: https://orcid.org/0000-0003-3379-7469)
- Pierandrea De Iaco (ORCID: https://orcid.org/0000-0002-8841-6531)
- Gloria Ravegnini (ORCID: https://orcid.org/0000-0002-7774-402X)
- Sarah Monesmith
- Francesco Mezzapesa
- Sara Bandini
Institutions
- University of Salento (IT)
- Italian Institute of Technology (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Azienda USL di Bologna (IT)
- Center for Biomolecular Nanotechnologies (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Institute for Microelectronics and Microsystems (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s10020-025-01177-7
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Fondazione Cassa di Risparmio in Bologna
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca