"Antibiotic-Responsive" Drug Fever Due to the Patient’s Medication-Taking Behavior: A Case Report

<p><strong>Background:</strong> Drug fever can complicate the diagnosis of recurrent fever, especially when multiple physicians are involved in treatment.</p> <p><br /><strong>Case Presentation:</strong> We report the case of a 56-year-old man with recurrent fever responsive to antibiotics, initially suggesting a persistent bacterial infection. Detailed history-taking revealed that he discontinued minocycline, prescribed for rosacea dermatitis, when starting new antibiotics, and resumed it after the fever subsided. Eosinophilia and a clear improvement in the general condition between fevers led to the suspicion of drug fever. A rechallenge confirmed minocycline-induced fever.</p> <p><br /><strong>Conclusion</strong>: This case emphasizes the importance of thoroughly reviewing medication history and patients’ medication-taking behavior when drug fever is suspected. </p>