Relationships between blood pressure indicators and fluid biomarkers of brain aging in functionally intact older adults
Our findings suggest that elevated pulse pressure, and to a lesser extent systolic blood pressure, are associated with increased Alzheimer's disease and neurodegenerative (axonal and astrocytic health) biology among typically aging adults. These associations underscore the importance of blood pressure management, particularly pulse pressure, for reducing dementia risk. Cardiovascular health may be incorporated with biomarkers to further personalize dementia prevention and management strategies.
Authors
- Anna M. VandeBunte (ORCID: https://orcid.org/0000-0002-5167-3358)
- Shubir Dutt (ORCID: https://orcid.org/0000-0002-8408-2220)
- Brandon Chan (ORCID: https://orcid.org/0000-0002-9450-4220)
- Rowan Saloner (ORCID: https://orcid.org/0000-0002-1351-6183)
- Kaitlin Blackstone Casaletto (ORCID: https://orcid.org/0000-0001-5000-7604)
- Claire J. Cadwallader (ORCID: https://orcid.org/0000-0003-3449-3803)
- Julio C. Rojas (ORCID: https://orcid.org/0000-0002-5730-5388)
- Isabel J. Sible (ORCID: https://orcid.org/0000-0003-3922-0628)
- Bailey L Ortiz
- Valentina Díaz (ORCID: https://orcid.org/0009-0004-6052-9982)
- Emily W. Paolillo (ORCID: https://orcid.org/0000-0003-4188-6998)
- Joel H. Kramer (ORCID: https://orcid.org/0000-0002-1206-404X)
- Argentina Lario Lago
- Coty Chen
Institutions
- Palo Alto University (US)
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s13195-025-01731-9
- Citations
- 4
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- Alzheimer's Association
- Larry L. Hillblom Foundation
- National Institutes of Health
- National Institute on Aging