NEW TETRACYCLIC THIENO[3,2-d]PYRIMIDINE SCAFFOLD DERIVATIVES SYNTHESIZED AND AMINATED

The synthesis of novel thieno[3,2-d]pyrimidine derivatives started with the reaction of 5-bromo-2 chlorobenzonitrile with ethyl-2-mercaptoacetate to give the compound AT-2. The addition of lactames to the formed AT-2 followed by cyclization gave the compound AR-05. The amination reaction was then used to facilitate the formation of a C-C bond. The intermediate AR-05 was formed under a base in dioxane in the presence of aromatic amines and a palladium catalyst, forming a new nitrogen-carbon bond. AR-58-1 and AR-82 were synthesized as end products. The structure of the new compounds was studied by analyzing the results obtained by studying their physical and physico-chemical properties.