Npc1 gene mutation impairs multilineage differentiation potential of hepatic telocytes in murine models
Our findings demonstrate that NPC1 deficiency markedly attenuates hepatic TCs' multipotency of liver TCs to differentiate into adipocytes, osteoblasts, and cardiocytes, suggesting that NPC1 protein might affect the pluripotency of TCs by regulating the lipid transport pathway. This finding provides novel insights into TC-mediated mechanisms in NPC pathology and lays a theoretical foundation for regenerative medicine strategies targeting TCs.
Authors
- Jichao Yang (ORCID: https://orcid.org/0000-0002-2733-5076)
- Liang Qiao (ORCID: https://orcid.org/0000-0002-4638-3225)
- Ganesh Dama
- Yuqiao Chang (ORCID: https://orcid.org/0000-0001-7549-4402)
- Yongli Lou (ORCID: https://orcid.org/0000-0002-1671-7327)
- Juntang Lin (ORCID: https://orcid.org/0000-0003-0665-1413)
Institutions
- Zhengzhou Central Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Cell Biology and Toxicology
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1007/s10565-025-10018-6
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00