<scp>EEG</scp> Spectral Exponents and Visual Chirp Responses Mirror Anti‐Seizure Medication Load in Refractory Focal Epilepsy
Resting state EEG spectral exponents and visual chirp responses reflect ASM load in refractory epilepsy. Low-frequency spectral changes in resting state EEG may only mirror ASM-induced spectral slowing. Visual chirp stimulation reveals enhanced harmonic EEG responses during low ASM loads, likely due to both increased high gamma activity and increased response to visual perturbations. Implementation of the markers would need normative values to reduce the delay to individually optimised treatment regimens.
Authors
- Silvano R. Gefferie (ORCID: https://orcid.org/0000-0002-0881-9315)
- Arn M. J. M. van den Maagdenberg (ORCID: https://orcid.org/0000-0002-9310-5535)
- Roland D. Thijs (ORCID: https://orcid.org/0000-0003-1435-8970)
- Gerhard H. Visser (ORCID: https://orcid.org/0000-0001-6708-6396)
- Arthur R. van Nieuw Amerongen (ORCID: https://orcid.org/0000-0001-8375-5975)
- Maeike Zijlmans (ORCID: https://orcid.org/0000-0003-1258-5678)
- Else A. Tolner (ORCID: https://orcid.org/0000-0002-6501-9971)
- Mark van de Ruit (ORCID: https://orcid.org/0000-0003-3806-2031)
Institutions
- Leiden University (NL)
- Leiden University Medical Center (NL)
- University Medical Center Utrecht (NL)
- National Hospital for Neurology and Neurosurgery (GB)
- Stichting Epilepsie Instellingen Nederland (NL)
- University College London (GB)
- Delft University of Technology (NL)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1002/acn3.70045
- Primary Topic
- EEG and Brain-Computer Interfaces
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Health~Holland
- ZonMw
- Medical Delta