Treatment Efficacy and Molecular Dynamics of Neoadjuvant Durvalumab and Olaparib in Resectable Urothelial Bladder Cancer: The NEODURVARIB Trial
The combination of neoadjuvant durvalumab and olaparib shows therapeutic activity in bladder cancer. Resistance mechanisms seem to be driven by transcriptional adaptations rather than the emergence of new mutations.
Authors
- Jesús García-Donás (ORCID: https://orcid.org/0000-0001-7731-3601)
- Rodrigo Madurga (ORCID: https://orcid.org/0000-0002-1381-2599)
- Cristina Rodríguez‐Antona (ORCID: https://orcid.org/0000-0001-8750-7338)
- Albert Font (ORCID: https://orcid.org/0000-0003-3908-1111)
- Elena Sevillano-Fernández
- Carlos Álvarez-Fernández (ORCID: https://orcid.org/0000-0002-2500-074X)
- Juan Francisco Rodríguez-Moreno (ORCID: https://orcid.org/0000-0001-7510-5059)
- Ricardo Fernández (ORCID: https://orcid.org/0009-0001-2331-135X)
- Luis Beltrán (ORCID: https://orcid.org/0009-0003-5375-6821)
- Sergio Ruiz‐Llorente (ORCID: https://orcid.org/0000-0002-5003-1759)
- Pedro Berraondo (ORCID: https://orcid.org/0000-0001-7410-1865)
- Pablo Gajate (ORCID: https://orcid.org/0000-0001-5156-7080)
- Ricardo Collado (ORCID: https://orcid.org/0000-0002-7666-9902)
- Osvaldo Graña‐Castro (ORCID: https://orcid.org/0000-0003-1615-4242)
- Núria Laínez
- Guillermo de Velasco (ORCID: https://orcid.org/0000-0002-8075-0666)
- Juan Antonio Virizuela
- Sergio Vázquez (ORCID: https://orcid.org/0000-0002-4973-3198)
Institutions
- Universidad San Pablo CEU (ES)
- Institut Català d'Ornitologia (ES)
- Universidad de Alcalá (ES)
- Barts Health NHS Trust (GB)
- Universidad Francisco de Vitoria (ES)
- Spanish National Cancer Research Centre (ES)
- Hospital Universitario Virgen Macarena (ES)
- Complejo Hospitalario de Navarra (ES)
- Hospital Universitario 12 De Octubre (ES)
- Institut Català d'Oncologia (ES)
- Navarre Institute of Health Research (ES)
- HM Hospitales (ES)
- Hospital Universitario Central de Asturias (ES)
- Hospital de Cruces (ES)
- Hospital Universitario HM Sanchinarro (ES)
- Hospital Universitario Lucus Augusti (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
- Complejo Hospitalario de Cáceres (ES)
- Hospital Universitario Ramón y Cajal (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2890
- Citations
- 1
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01