Prognostic Value of CD8+ T Cells at the Invasive Margin Is Comparable to the Immune Score in Nonmetastatic Colorectal Cancer: A Prospective Multicentric Cohort Study
CD8-IM alone provided prognostic information comparable with the ICS. Simplified, cost-effective TIL assessments could improve clinical translation and guide adjuvant therapy in early-stage colorectal cancer.
Authors
- Dominic Edelmann (ORCID: https://orcid.org/0000-0001-7467-6343)
- Michael Hoffmeister (ORCID: https://orcid.org/0000-0002-8307-3197)
- Durgesh Wankhede (ORCID: https://orcid.org/0000-0003-2583-9032)
- Niels Halama (ORCID: https://orcid.org/0000-0003-0344-6027)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Matthias Kloor (ORCID: https://orcid.org/0000-0002-4125-992X)
Institutions
- German Cancer Research Center (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- National Center for Tumor Diseases (DE)
- Helmholtz Institute Mainz (DE)
- Heidelberg University (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-3275
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung