Calpain inhibition as a novel therapeutic strategy for aortic dissection with acute lower extremity ischemia
Inhibition of Calpain has been demonstrated to decrease the incidence of AD and enhance the restoration of blood flow perfusion in ischemic lower extremities. This effect may be mediated by the upregulation of Fabp3. These findings highlight the potential for targeted interventions against Calpain as a novel therapeutic strategy in the treatment of cardiovascular disease.
Authors
- Kun Song (ORCID: https://orcid.org/0000-0002-7831-8794)
- Wenxue Ye (ORCID: https://orcid.org/0000-0001-9917-2176)
- Wanchuang Xu
- Jingjing Li (ORCID: https://orcid.org/0000-0001-8000-7410)
- Xiaokang Wang (ORCID: https://orcid.org/0000-0002-4325-9907)
- Qiwen Tan
- Zhenya Shen (ORCID: https://orcid.org/0000-0001-6503-6571)
- Xiaomei Teng (ORCID: https://orcid.org/0000-0002-2975-2957)
- Yifan Xiong (ORCID: https://orcid.org/0000-0002-0544-049X)
- Yunsheng Yu
- Zhengming Jiang
Institutions
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s10020-025-01212-7
- Citations
- 2
- Primary Topic
- Calpain Protease Function and Regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province