Peptides targeting RAB11A–FIP2 complex inhibit HPIV3, RSV, and IAV replication as broad-spectrum antivirals
This work introduces a promising broad-spectrum antiviral strategy for respiratory tract infections by targeting the RAB11A-FIP2 complex, which regulates the transport and assembly of viral RNA. By disrupting this pathway, YT-DRI effectively inhibits the replication of multiple respiratory RNA viruses, including HPIV3, RSV, and IAV.
Authors
- Xiaoyan Wu (ORCID: https://orcid.org/0000-0001-8903-9785)
- Yanliang Jiang
- Yali Qin (ORCID: https://orcid.org/0000-0001-8746-4956)
- Jie Deng (ORCID: https://orcid.org/0000-0002-9594-5642)
- Jian Li (ORCID: https://orcid.org/0000-0001-9434-7803)
- Yongliang Zhao
- Mingzhou Chen (ORCID: https://orcid.org/0000-0002-1421-0960)
- Dong Guo
- Ke Xu (ORCID: https://orcid.org/0000-0002-0471-0523)
Institutions
- Wuhan University (CN)
- Wuhan Institute of Virology (CN)
- Hubei University of Technology (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s13578-025-01384-z
- Citations
- 2
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- Sun Yat-sen University Cancer Center