Improvement of the inflammation-damaged intestinal barrier and modulation of the gut microbiota in ulcerative colitis after FMT in the SHIME® model
FMT favorably modulates the gut microbiota of UC patient cultured in the SHIME® model. FMT-modulated SHIME-derived microbial metabolites improve intact and inflamed intestinal barrier properties in vitro. Repeated applications are necessary to maintain the beneficial effect of FMT in SHIME® model.
Authors
- Monika Kvaková (ORCID: https://orcid.org/0000-0002-9659-5584)
- Izabela Bertková (ORCID: https://orcid.org/0000-0003-3076-2711)
- Anna Kamlárová (ORCID: https://orcid.org/0000-0001-7871-5338)
- Zdenka Hertelyová (ORCID: https://orcid.org/0000-0003-1552-7115)
- René Link (ORCID: https://orcid.org/0000-0002-3302-2244)
- Ľuboš Ambro (ORCID: https://orcid.org/0000-0003-4398-1665)
- Emília Hijová (ORCID: https://orcid.org/0000-0002-8259-373X)
- Martin Janíčko (ORCID: https://orcid.org/0000-0002-3329-3968)
- Jana Štofilová (ORCID: https://orcid.org/0000-0002-9409-4153)
Institutions
- University of Pavol Jozef Šafárik (SK)
Publication Details
- Journal
- BMC Complementary Medicine and Therapies
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1186/s12906-025-04889-9
- Citations
- 4
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 7.27
Funders
- Agentúra na Podporu Výskumu a Vývoja
- European Regional Development Fund