Reduced AKT activation accompanied with high TP53 expression is implicated in the impaired hematogenesis in Ziegler-Huang syndrome and the Znt7 null mice partially recapitulates the human disease linked to pancytopenia
Excessive expression of TP53 and down-regulation of AKT activation induced by ZNT7 deficiency might impair cell survival, which may contribute to the pathophysiology of bone marrow failure in affected individuals with BMF8.
Authors
- Isabelle Pellier (ORCID: https://orcid.org/0000-0002-7988-4712)
- Stéphanie Nguyen (ORCID: https://orcid.org/0000-0003-4880-8220)
- Marie‐Christine Copin (ORCID: https://orcid.org/0000-0002-4729-7054)
- Charline Miot (ORCID: https://orcid.org/0000-0002-4586-1061)
- Liping Huang (ORCID: https://orcid.org/0000-0003-1217-0114)
- Coralie Mallebranche
- Odile Blanchet (ORCID: https://orcid.org/0000-0002-8275-8741)
- Clément Prouteau (ORCID: https://orcid.org/0000-0002-2986-5599)
- Alban Ziegler (ORCID: https://orcid.org/0000-0003-0287-3561)
- Zhongyue Yang
- Catherine P. Kirschke (ORCID: https://orcid.org/0000-0002-8403-3322)
- Dominique Bonneau (ORCID: https://orcid.org/0000-0002-6886-0969)
- R. Coutant (ORCID: https://orcid.org/0000-0002-6332-4243)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- West Health (US)
- Western Human Nutrition Research Center (US)
- Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes Angers (FR)
- Hôpital Larrey (FR)
- Université d'Angers (FR)
- University of California, Davis (US)
Publication Details
- Journal
- Journal of Trace Elements in Medicine and Biology
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.jtemb.2025.127658
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00