Prolonged fasting promotes systemic inflammation and platelet activation in humans: A medically supervised, water-only fasting and refeeding study
While the acute inflammatory response during PF may serve as a transient adaptive mechanism, it raises concerns regarding potential cardiometabolic effects that could persist after refeeding. Further investigation is warranted to elucidate the long-term molecular and clinical implications of PF across diverse populations.
Authors
- Brian Keith Kennedy (ORCID: https://orcid.org/0000-0002-5754-1874)
- Andrius Masedunskas (ORCID: https://orcid.org/0000-0002-4533-5467)
- Kristopher M. Kirmess (ORCID: https://orcid.org/0000-0002-0306-323X)
- Luigi Fontana (ORCID: https://orcid.org/0000-0001-8500-5537)
- Gayathiri Rajakumar (ORCID: https://orcid.org/0000-0002-8626-6170)
- Valeria Tosti
- Duaa Hatem (ORCID: https://orcid.org/0009-0005-5992-0201)
- Matthew R. Meyer (ORCID: https://orcid.org/0000-0002-4919-6927)
- Alan Goldhamer (ORCID: https://orcid.org/0000-0002-4120-3694)
- Bianca Rocca (ORCID: https://orcid.org/0000-0001-8304-6423)
- Giovanna Petrucci (ORCID: https://orcid.org/0000-0002-9280-3673)
- María Lastra Cagigas (ORCID: https://orcid.org/0000-0001-5464-2349)
- Giovanni Fiorito (ORCID: https://orcid.org/0000-0002-7651-5452)
- Serena Commissati
- Isabella De Ciutiis
Institutions
- University of Verona (IT)
- The University of Sydney (AU)
- Washington University in St. Louis (US)
- Royal Prince Alfred Hospital (AU)
- Istituto Giannina Gaslini (IT)
- C2N Diagnostics (United States) (US)
- National University Health System (SG)
- University of Florence (IT)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.molmet.2025.102152
- Citations
- 10
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 11.64