Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression
uCCR represents a surrogate for histologic quantification of p21<sup>+</sup>Ki67<sup>-</sup> senescent renal epithelia and predicts outcomes in human kidney disease independent of existing clinical risk factors.
Authors
- Piotr P. Janas (ORCID: https://orcid.org/0000-0001-5422-258X)
- Marie-Helena Docherty
- David A. Ferenbach (ORCID: https://orcid.org/0000-0002-9202-1428)
- Andy Nam (ORCID: https://orcid.org/0000-0003-1857-2245)
- David Baird (ORCID: https://orcid.org/0000-0002-6338-3788)
- Ross Campbell (ORCID: https://orcid.org/0000-0003-2298-9887)
- Patrick Barry Mark (ORCID: https://orcid.org/0000-0003-3387-2123)
- Laura Denby (ORCID: https://orcid.org/0000-0003-1277-708X)
- Matthieu Vermeren (ORCID: https://orcid.org/0000-0003-3584-0387)
- Thomas G. Mason (ORCID: https://orcid.org/0000-0002-7858-6537)
- Katie J. Mylonas (ORCID: https://orcid.org/0000-0002-7324-4597)
- Jeremy Hughes (ORCID: https://orcid.org/0000-0002-3470-0422)
- Jamie P. Traynor (ORCID: https://orcid.org/0000-0002-4339-0366)
- Nathan Schurman (ORCID: https://orcid.org/0009-0005-4834-4704)
- Bryan R. Conway (ORCID: https://orcid.org/0000-0002-2888-9249)
- Wei Yang (ORCID: https://orcid.org/0000-0001-5704-2277)
- Claire Williams (ORCID: https://orcid.org/0000-0003-4452-671X)
- Maximilian Reck
- Zenuida Mortuza
Institutions
- Bruker (United States) (US)
- Centre for Inflammation Research (GB)
- The Queen's Medical Research Institute (GB)
- University of Glasgow (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.ekir.2025.04.035
- Citations
- 5
- Primary Topic
- Clusterin in disease pathology
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- Wellcome Trust
- Kidney Research UK
- Medical Research Council