Global Burden Analysis in Pulmonary Arterial Hypertension among Women of Reproductive Age: Trends & Projections

Background: Pulmonary arterial hypertension (PAH) represents a substantial global public health burden, particularly among women of reproductive age, who face significant risks during pregnancy if affected by the condition. This study seeks to provide a thorough evaluation of the disease burden and trends of PAH in women of reproductive age (WPAH), aiming to guide the development of targeted prevention and control strategies. Methods: Data on the incidence, prevalence, disability-adjusted life years (DALYs), and deaths of WPAH were extracted from the Global Burden of Disease study (GBD) database for the years 1990 to 2021. Age-standardized rate (ASR) of incidence (ASIR) and ASR of prevalence (ASPR), ASR of DALYs (ASDR), and ASR of mortality(ASMR) were calculated at global, regional and national level, stratified by sociodemographic index (SDI) and age, to assess percentage changes and estimated annual percentage change (EAPC).