Iodo-decarboxylation of Aliphatic Carboxylic Acids with PhI(OAc)<sub>2</sub> and CHI<sub>3</sub> under Ambient Conditions
We have developed a mild and practical synthesis of primary, secondary and tertiary alkyl iodides by iododecarboxylation (decarboxylative iodination) of the corresponding carboxylic acids using (diacetoxyiodo)benzene and iodoform under ambient conditions. The method does not require heating or intense light irradiation and can be used to install iodine at the bridgehead position of strained cycloalkanes, as well as in a variety of alkanes with complex frameworks/functionalities.
Authors
- Kazunori Miyamoto (ORCID: https://orcid.org/0000-0003-1423-6287)
- Tadafumi Matsunaga
- Shinichiro Kamino (ORCID: https://orcid.org/0000-0002-1133-1425)
- Marie Kubota (ORCID: https://orcid.org/0000-0002-5059-9387)
- Kyoka Sakamoto (ORCID: https://orcid.org/0000-0002-3254-1149)
- Masanobu Uchiyama (ORCID: https://orcid.org/0000-0001-6385-5944)
Institutions
- Aichi Gakuin University (JP)
- Keio University (JP)
- The University of Tokyo (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1021/acs.orglett.5c00924
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Naito Foundation
- Asahi Glass Foundation
- Uehara Memorial Foundation
- Nagase Science Technology Foundation
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology