Immediate postoperative effects of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy using carboplatin on peritoneal tissue inflammatory and ischemic responses: an explorative porcine study
In a porcine model, CRS with HIPEC leads to an immediate and relatively constant increased inflammatory and ischemic peritoneal tissue short-time response. The explorative findings contribute to the debate on the value of HIPEC in combination with CRS and call for future studies to further investigate the inflammatory and metabolic tissue responses.
Authors
- Mats Bue (ORCID: https://orcid.org/0000-0001-7215-8323)
- Pelle Hanberg (ORCID: https://orcid.org/0000-0002-6845-1874)
- Elisabeth Krogsgaard Petersen (ORCID: https://orcid.org/0000-0002-5164-5197)
- Andrea René Jørgensen (ORCID: https://orcid.org/0000-0001-6334-3164)
- Christina Harlev (ORCID: https://orcid.org/0000-0001-7255-9557)
- Maiken Stilling (ORCID: https://orcid.org/0000-0002-4530-2075)
- Lone Kjeld Petersen (ORCID: https://orcid.org/0000-0002-1424-6170)
Institutions
- University of Southern Denmark (DK)
- Aarhus University (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Pleura and Peritoneum
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1515/pp-2025-0001
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Arvid Nilssons Fond
- Aarhus Universitet
- Aarhus Universitetshospital
- Danish Cancer Society Research Center
- Vissing Fonden
- Helga og Peter Kornings Fond
- Riisfort Fonden
- Torben og Alice Frimodts Fond
- Familien Hede Nielsens Fond
- Frimodt-Heineke Fonden
- Læge Agnethe Løvgreens Legat
- Knud og Edith Eriksens Mindefond
- Fonden til Lægevidenskabens Fremme