Prognostic Value of the Circulating Tumor DNA Fraction in Metastatic Castration-resistant Prostate Cancer: Results from the ProBio Platform Trial
Undetectable ctDNA at baseline predicts superior prognosis in mCRPC, suggesting potential for treatment de-escalation and less intensive monitoring for this subgroup of patients. This trial is registered on ClinicalTrials.gov as NCT03903835.
Authors
- Sanne D’hondt (ORCID: https://orcid.org/0000-0002-7604-3117)
- Camilla Thellenberg‐Karlsson (ORCID: https://orcid.org/0000-0002-7061-7255)
- Ashkan Mortezavi (ORCID: https://orcid.org/0000-0001-6307-2659)
- Maria Persson (ORCID: https://orcid.org/0000-0002-3128-0805)
- Jochen Darras
- S. Johansson (ORCID: https://orcid.org/0000-0002-0073-6355)
- Henrik Grönberg (ORCID: https://orcid.org/0000-0002-1073-2753)
- Ingrida Verbiené
- Johan Sandzén
- Michiel Strijbos (ORCID: https://orcid.org/0000-0003-2390-3029)
- Johan Lindberg (ORCID: https://orcid.org/0000-0003-3610-6774)
- Daan De Maeseneer (ORCID: https://orcid.org/0000-0002-0339-5621)
- Christophe Ghysel
- Bram De Laere (ORCID: https://orcid.org/0000-0002-1174-0384)
- Peter Schatteman (ORCID: https://orcid.org/0000-0001-5709-5643)
- Siska Van Bruwaene (ORCID: https://orcid.org/0000-0001-9815-3109)
- Gunilla Enblad (ORCID: https://orcid.org/0000-0002-0594-724X)
- Martin Eklund (ORCID: https://orcid.org/0000-0001-5032-5266)
- Brieuc Sautois (ORCID: https://orcid.org/0000-0002-0029-7735)
- Mats Anden
- Daisy Luyten (ORCID: https://orcid.org/0009-0009-3917-7587)
- Piet Ost (ORCID: https://orcid.org/0000-0002-2203-4848)
- Wendy De Roock
- Nicolaas Lumen (ORCID: https://orcid.org/0000-0003-1242-3644)
- Elin Jänes
- Marie Hjälm-Eriksson
- Anders Ullén (ORCID: https://orcid.org/0000-0002-9023-3259)
- Els Everaert (ORCID: https://orcid.org/0000-0002-8874-6602)
- Alessio Crippa (ORCID: https://orcid.org/0000-0002-2254-2420)
- Jan Oldenburg
- Andrea Discacciati
- Martha Olsson
- Berit Larsson
- Linn Pettersson
Institutions
- Karolinska University Hospital (SE)
- Uppsala University Hospital (SE)
- Science for Life Laboratory (SE)
- Akershus University Hospital (NO)
- AZ Groeninge (BE)
- Ghent University Hospital (BE)
- Karolinska Institutet (SE)
- Jessa Hospital (BE)
- Saint Göran Hospital (SE)
- University Hospital of Zurich (CH)
- Onze Lieve Vrouwziekenhuis Hospital (BE)
- Karlstad Central Hospital (SE)
- Vlaamse Vereniging voor Obstetrie en Gynaecolo (BE)
- Damiaan Dicht bij het leven (BE)
- Länssjukhuset i Kalmar (SE)
- Centrallasarettet Växjö (SE)
- Ziekenhuis Oost-Limburg (BE)
- AZ Sint-Lucas (BE)
- Umeå University (SE)
Publication Details
- Journal
- European Urology Oncology
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.euo.2025.02.002
- Citations
- 4
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 6.07