Breath Analysis of Propofol and Associated Metabolic Signatures: A Pilot Study Using Secondary Electrospray Ionization–High-resolution Mass Spectrometry
This pilot study highlights a robust breath-serum relationship for propofol and reveals surgery-associated shifts in metabolic pathways, including evidence of oxidative stress. These findings underscore the feasibility of exhaled-breath pharmacometabolomics for individualized anesthetic care. Further validation in larger cohorts is warranted to confirm clinical utility and to determine whether real-time breath analysis could ultimately serve as a useful adjunct for guiding anesthetic management and monitoring perioperative metabolic responses.
Authors
- Kapil Dev Singh (ORCID: https://orcid.org/0000-0002-5682-0708)
- Nikola Stanković (ORCID: https://orcid.org/0000-0002-8053-4488)
- Pablo Sinues (ORCID: https://orcid.org/0000-0001-5602-2880)
- Jiafa Zeng (ORCID: https://orcid.org/0000-0002-9425-0371)
- R. Steiner (ORCID: https://orcid.org/0009-0001-1617-6524)
- Urs Frey (ORCID: https://orcid.org/0000-0003-3773-2822)
- Thomas O. Erb (ORCID: https://orcid.org/0000-0001-9263-2352)
Institutions
- University of Basel (CH)
- University Hospital of Basel (CH)
- University Hospital of Zurich (CH)
- University Children’s Hospital Basel (CH)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Anesthesiology
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1097/aln.0000000000005531
- Citations
- 4
- Primary Topic
- Advanced Chemical Sensor Technologies
- Type
- article
- Field-Weighted Citation Impact
- 2.70