Associations of Urine Biomarkers During Ambulatory Acute Kidney Injury With Subsequent Recovery in Kidney Function: Findings From the SPRINT Study
Increases in serum creatinine concentration can occur when treating hypertension and complicate clinical management, but there are few tools available to distinguish whether an individual's kidney function will subsequently recover. In this study, we investigated the association of kidney biomarkers measured in the urine with subsequent kidney function among individuals in the outpatient setting in whom an increase in serum creatinine occurs. We found that biomarkers reflecting worse glomerular injury and tubular dysfunction are associated with the risk of an individual's kidney function not recovering. These results suggest that a broader assessment of kidney health when serum creatinine increases in the outpatient setting may help distinguish subsequent trajectories in kidney function.
Authors
- Rebecca Scherzer (ORCID: https://orcid.org/0000-0002-1579-5390)
- Stein Hallan (ORCID: https://orcid.org/0000-0002-9045-3569)
- Nicholas Wettersten (ORCID: https://orcid.org/0000-0002-6122-1152)
- Ronit Katz (ORCID: https://orcid.org/0000-0001-7723-7469)
- Joachim H. Ix (ORCID: https://orcid.org/0000-0002-8084-9869)
- Pranav Sandilya Garimella (ORCID: https://orcid.org/0000-0002-6016-4715)
- Alexander L. Bullen (ORCID: https://orcid.org/0000-0001-6864-0336)
- Michelle M. Estrella (ORCID: https://orcid.org/0000-0002-8902-9576)
- Simon B. Ascher (ORCID: https://orcid.org/0000-0003-3465-4208)
- Teresa K. Chen (ORCID: https://orcid.org/0000-0003-0106-050X)
- Alfred K. Cheung (ORCID: https://orcid.org/0000-0002-7304-9476)
- Michael G. Shlipak
Institutions
- University of California, San Francisco (US)
- University of Washington (US)
- Norwegian University of Science and Technology (NO)
- University of Utah (US)
- University of California San Diego (US)
- VA San Diego Healthcare System (US)
- St Olav's University Hospital (NO)
- San Francisco VA Health Care System (US)
Publication Details
- Journal
- American Journal of Kidney Diseases
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1053/j.ajkd.2025.02.607
- Citations
- 3
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.16
Funders
- American Heart Association
- Vanderbilt University
- George Washington University
- Wake Forest University
- University of Michigan
- University of Florida
- University of Utah
- Tulane University
- University of Pittsburgh
- Case Western Reserve University
- University of Illinois System
- National Institutes of Health
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Neurological Disorders and Stroke
- National Center for Advancing Translational Sciences