Investigating the relationship between toll-like receptor activity, low-grade inflammation and cognitive deficits in schizophrenia patients – A mediation analysis
We have demonstrated that patients with schizophrenia have elevated protein and mRNA expression of a range of cytokines and Toll-like receptors. Some of these changes are associated with deficits in cognition. Finally, our study has demonstrated a modest relationship between TLR activity and cognitive deficits in schizophrenia patients in a manner that may be mediated by IL-6 and IL-8.
Authors
- Saahithh Redddi Patlola (ORCID: https://orcid.org/0000-0003-4367-1720)
- Gary J Donohoe (ORCID: https://orcid.org/0000-0003-3037-7426)
- Brian P. Hallahan (ORCID: https://orcid.org/0000-0003-0518-9757)
- John Kelly (ORCID: https://orcid.org/0000-0001-5548-2738)
- Ross McManus (ORCID: https://orcid.org/0000-0002-0529-9617)
- Laurena Holleran (ORCID: https://orcid.org/0000-0002-8354-3670)
- Derek W. Morris (ORCID: https://orcid.org/0000-0002-3413-570X)
- Maria R. Dauvermann (ORCID: https://orcid.org/0000-0002-2873-8512)
- Declan P. McKernan (ORCID: https://orcid.org/0000-0002-9691-1671)
- Marcus Kenyon (ORCID: https://orcid.org/0000-0002-4664-2776)
- Aodán Laighneach (ORCID: https://orcid.org/0000-0003-4853-8953)
- Karolina Rokita (ORCID: https://orcid.org/0000-0002-3816-2617)
- Colm McDonald
Institutions
- Ollscoil na Gaillimhe – University of Galway (IE)
- Trinity College Dublin (IE)
- St. James's Hospital (IE)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.bbi.2025.04.024
- Citations
- 4
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.31
Funders
- University of Galway
- European Research Council
- College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway
- H2020 European Research Council