Ontology accelerates few-shot learning capability of large language model: A study in extraction of drug efficacy in a rare pediatric epilepsy
The new ontology-augmented PCL approach significantly accelerates the few-shot learning capabilities of the Gemini LLM, thereby reducing the number of required examples and time needed to optimize LLMs for medical applications.
Authors
- Dennis Lal (ORCID: https://orcid.org/0000-0002-5173-9636)
- Katrina Prantzalos (ORCID: https://orcid.org/0000-0003-4009-2950)
- Howard P. Goodkin (ORCID: https://orcid.org/0000-0003-0528-4949)
- Kelly G. Knupp (ORCID: https://orcid.org/0000-0002-1967-0827)
- Brandy Fureman (ORCID: https://orcid.org/0000-0002-7862-4716)
- Jack M. Parent (ORCID: https://orcid.org/0000-0002-2972-1528)
- Satya S. Sahoo (ORCID: https://orcid.org/0000-0001-9190-4256)
- Jeffrey A. Loeb (ORCID: https://orcid.org/0000-0003-2980-6377)
- Mary Anne Meskis (ORCID: https://orcid.org/0000-0003-0748-7774)
- Lauren C. Harte‐Hargrove (ORCID: https://orcid.org/0000-0001-5678-9184)
- Pedram Golnari (ORCID: https://orcid.org/0000-0002-2154-1645)
- Veronica L. Hood (ORCID: https://orcid.org/0000-0002-1988-4980)
- Elaine C. Wirrell (ORCID: https://orcid.org/0000-0003-3015-8282)
- Karen S. Wilcox (ORCID: https://orcid.org/0000-0003-2660-8826)
- Jeffrey Buchhalter (ORCID: https://orcid.org/0000-0002-6807-8328)
- Joseph Sullivan (ORCID: https://orcid.org/0000-0003-2081-8988)
- Lori L. Isom (ORCID: https://orcid.org/0000-0002-9479-6729)
- Samden Lhatoo (ORCID: https://orcid.org/0000-0002-0260-3855)
- Manisha Patel (ORCID: https://orcid.org/0000-0003-2943-0920)
Institutions
- Mayo Clinic (US)
- University of Calgary (CA)
- University of Utah (US)
- University of Michigan (US)
- Dravet Syndrome Foundation (US)
- Epilepsy Foundation (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- UCSF Benioff Children's Hospital (US)
- Mayo Clinic in Florida (US)
- Epilepsy Foundation (AU)
- University of Virginia (US)
- University of Colorado Anschutz Medical Campus (US)
- Case Western Reserve University (US)
- University of Montana (US)
- The University of Texas Health Science Center at Houston (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- International Journal of Medical Informatics
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.ijmedinf.2025.105942
- Citations
- 2
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.94