Palmitic acid enhances the sensitivity of ferroptosis via endoplasmic reticulum stress mediated the ATF4/TXNIP Axis in polycystic ovary syndrome
PA stimulated ovarian ferroptosis by activating ER stress, a process mediated by the ATF4/TXNIP axis, which might represent a potential mechanism underlying the progression of PCOS. The application of ER stress inhibitors improved PCOS traits by reducing the sensitivity of ovarian ferroptosis.
Authors
- Chunmei Bai
- Ting Luo (ORCID: https://orcid.org/0000-0002-9670-4031)
- Yang Li (ORCID: https://orcid.org/0000-0003-4399-1505)
- Haixia Song
- Jianrong Liu (ORCID: https://orcid.org/0000-0001-8163-7529)
- Ziwei Huang (ORCID: https://orcid.org/0000-0001-5459-1211)
- Yanxin Fan (ORCID: https://orcid.org/0000-0002-7207-9331)
- Xumin Zhang (ORCID: https://orcid.org/0000-0002-8231-2600)
Institutions
- Shanxi Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.phymed.2025.156777
- Citations
- 5
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 7.59