A pre-existing chronic Toxoplasma gondii infection promotes epileptogenesis and neuropathology in a mouse model of mesial temporal lobe epilepsy
These findings demonstrate that a chronic T. gondii infection can result in epilepsy, and that a pre-existing T. gondii infection exacerbates epileptogenesis following a brain insult, in mice.
Authors
- Terence John O'Brien (ORCID: https://orcid.org/0000-0002-7198-8621)
- Michael J. Asmussen (ORCID: https://orcid.org/0000-0002-6692-9790)
- Tamara L. Baker
- Mujun Sun (ORCID: https://orcid.org/0000-0002-9923-9913)
- Idrish Ali (ORCID: https://orcid.org/0000-0002-0971-4654)
- Nigel C. Jones (ORCID: https://orcid.org/0000-0002-1080-8439)
- Ana Antonic‐Baker (ORCID: https://orcid.org/0000-0003-4275-7557)
- Trevor Wilson (ORCID: https://orcid.org/0009-0004-0776-9194)
- Peravina Thergarajan (ORCID: https://orcid.org/0000-0003-0778-7232)
- Pablo M. Casillas‐Espinosa (ORCID: https://orcid.org/0000-0002-6199-9415)
- Stuart J. McDonald (ORCID: https://orcid.org/0000-0001-5190-3179)
- David Wright (ORCID: https://orcid.org/0000-0002-7535-8651)
- Sandy R. Shultz (ORCID: https://orcid.org/0000-0002-2525-8775)
- Christopher J. Tonkin (ORCID: https://orcid.org/0000-0002-7036-6222)
- Anh Vo (ORCID: https://orcid.org/0000-0002-9156-0323)
- Alessandro D. Uboldi
Institutions
- The Royal Melbourne Hospital (AU)
- Walter and Eliza Hall Institute of Medical Research (AU)
- The Alfred Hospital (AU)
- Vancouver Island University (CA)
- Monash Health (AU)
- Monash University (AU)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1016/j.bbi.2025.04.026
- Citations
- 3
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.14
Funders
- Michael Smith Health Research BC
- Brain Foundation
- National Health and Medical Research Council