Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing
The effect of nimodipine goes beyond cerebral vasorelaxation. Nimodipine attenuates microglial activation by modulating Ca<sup>2+</sup>-dependent gene expression involved in intracellular signalling cascades to drive microglial immune responses. Consideration should be given to expanding the use of nimodipine beyond vasorelaxation.
Authors
- Eszter Farkas (ORCID: https://orcid.org/0000-0002-8478-9664)
- Rita Frank (ORCID: https://orcid.org/0000-0003-2342-9937)
- Erda Qorri (ORCID: https://orcid.org/0000-0002-4762-8386)
- D Kata (ORCID: https://orcid.org/0000-0002-4432-9380)
- Károly Gulya (ORCID: https://orcid.org/0000-0001-6864-4150)
- Ferenc Bari (ORCID: https://orcid.org/0000-0001-9383-452X)
- Ákos Menyhárt (ORCID: https://orcid.org/0000-0002-1355-3208)
- István Pesti (ORCID: https://orcid.org/0000-0001-9778-366X)
- Péter Archibald Szarvas
- V Varga
- Krisztián Vinga
Institutions
- University of Szeged (HU)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-04-21
- DOI
- https://doi.org/10.1111/bph.70060
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Magyar Tudományos Akadémia
- National Research, Development and Innovation Office