Molecular Mechanisms Contributing to the Impairment of Steroid Hormones, Sperm Characteristics, and Testicular Architecture in Male Rabbits After Chronic Exposure to Cadmium: Role of Gallic Acid and Selenium as Antioxidants
The lower levels of steroid hormones could be due to the downregulation of CYP11A1, inhibition of 17β-hydroxysteroid dehydrogenase, antioxidant enzyme activities, and the induction of free radical levels. Furthermore, the pretreatment of rabbits with gallic acid or selenium mitigated the adverse effects of cadmium on the tissue architecture of testes and steroid hormone levels.
Authors
- Salah A. Sheweita (ORCID: https://orcid.org/0000-0001-8113-4403)
- Mohamed S. Sheweita
- R.G. Ahmed (ORCID: https://orcid.org/0000-0002-9926-0624)
- A.A. Atta (ORCID: https://orcid.org/0000-0003-4939-404X)
- Saleh M. Al‐Qahtani
Institutions
- Southmead Hospital (GB)
- King Khalid University (SA)
- Alexandria University (EG)
Publication Details
- Journal
- Toxics
- Published
- 2025-04-21
- DOI
- https://doi.org/10.3390/toxics13040323
- Citations
- 4
- Primary Topic
- Heavy Metal Exposure and Toxicity
- Type
- article
- Field-Weighted Citation Impact
- 4.80