Direct hydroacylation of arylacrylonitriles toward β-ketonitriles assisted by an EDA complex

Here, we present a base-mediated direct hydroacylation reaction of arylacrylonitrile. This method provides an efficient approach for highly site-selective synthesis of β-ketonitriles, demonstrating mild, facile and high atom- and step-economical characteristics. The reaction occurs through a free-radical pathway enabled by an EDA complex in the absence of light.

Authors

Shiqing Huang (ORCID: https://orcid.org/0000-0002-6377-368X)
Huei‐Tse Hou (ORCID: https://orcid.org/0000-0003-1783-8830)
Zhenhui Wang (ORCID: https://orcid.org/0000-0002-7594-2276)
Wei Ou (ORCID: https://orcid.org/0000-0002-1760-8528)
Wei Liu (ORCID: https://orcid.org/0000-0003-0480-2097)

Institutions

Qilu University of Technology (CN)
Shenzhen University (CN)
San’an Optoelectronics (China) (CN)
Renmin University of China (CN)

Publication Details

Journal: Chemical Communications
Published: 2025-01-01
DOI: https://doi.org/10.1039/d5cc00867k
Citations: 2
Primary Topic: Asymmetric Hydrogenation and Catalysis
Type: article
Field-Weighted Citation Impact: 1.07

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article

Direct hydroacylation of arylacrylonitriles toward β-ketonitriles assisted by an EDA complex

Shiqing Huang, Huei‐Tse Hou, Zhenhui Wang, Wei Ou et al.

Jan 1, 2025

2 citations

Chemical Communications

Asymmetric Hydrogenation and Catalysis

1.07

article

Direct hydroacylation of arylacrylonitriles toward β-ketonitriles assisted by an EDA complex

Shiqing Huang, Huei‐Tse Hou, Zhenhui Wang, Wei Ou, Wei Liu

January 1, 2025article en

2 citations

Abstract

Here, we present a base-mediated direct hydroacylation reaction of arylacrylonitrile. This method provides an efficient approach for highly site-selective synthesis of β-ketonitriles, demonstrating mild, facile and high atom- and step-economical characteristics. The reaction occurs through a free-radical pathway enabled by an EDA complex in the absence of light.

Chemical CommunicationsVol. 61(41)

Qilu University of Technology (CN), Shenzhen University (CN), San’an Optoelectronics (China) (CN), Renmin University of China (CN)

Openalex Percentile: Top 24%

Asymmetric Hydrogenation and Catalysis

1.07

DOI Source OpenAlex

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