Abstract 2294: Association of analgesic use with risk of renal cell cancer in the Nurses’ Health Studies

Abstract Objectives: This study aims to investigate the association between commonly utilized analgesics—aspirin, non-aspirin nonsteroidal anti-inflammatory medications (NSAIDs), and acetaminophen and the risk of renal cell cancer (RCC) in women. Methods: In 1980, the Nurses’ Health Study (NHS) collected data on aspirin usage from 92, 125 women. Additional non-aspirin NSAIDs and acetaminophen were included in 1990. In 1989, 112, 292 women were collected data in the NHS II and followed up since 1989. The association was also further investigated by stratification of histological subtypes, pathologic stage, and differentiation subtypes for RCC. Cox proportional hazards models were employed to generate cohort-specific, multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) for each analgesic. Results from both cohorts were aggregated by random-effects meta-analyses. Results: For the over 20-year follow-up period, there are 11, 978, 22, 838, and 28, 350 women currently use acetaminophen, aspirin, and NSAIDs from the NHS study, and 25, 416, 12, 958, and 22, 407 women currently use these analgesic medications individually. 575 RCC and 142 fatal RCC cases were identified across the two cohorts. For RCC, in NHS II. We observed a significantly increased risk of RCC among the current acetaminophen users (Relative risk (RR): 1.56, 95%CI:1.13, 2.15). Pooled results showed positive associations: acetaminophen (RR:1.02, 95%CI: 0.75, 1.95); aspirin (RR:1.11, 95%CI: 0.91, 1.31); non-aspirin NSAIDs (RR:1.29, 95%CI:0.90, 1.83). Similar trends were observed for fatal RCC. When stratified the RCC subgroups, aspirin use shows a significantly positive association with the increased risk of different pathologic states (pooled RR: 1.29, 95%CI: 1.02, 1.63), and non-aspirin NSAID use was also associated with increased risk of different histological, pathological and differentiated RCC risk significantly. Conclusions: These data illustrated that the use of analgesics in NHS and NHS II cohorts is potentially associated with an increased risk of RCC among women. Citation Format: Jinhui Li, Minji Jung, Benjamin Chung, Mark Preston, Marvin Langston, Rebecca Graff. Association of analgesic use with risk of renal cell cancer in the Nurses’ Health Studies [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 2294.