Abstract 7366: Associations of inflammatory dietary patterns and predicted pro-inflammatory hs-CRP scores with health-related quality of life among breast cancer survivors

Abstract Backgrounds: Diet may modify chronic inflammation, which has a potential link with health-related quality of life (HRQoL) and cancer prognosis. This study investigated the associations of inflammatory dietary patterns and predicted pro-inflammatory hs-CRP scores with HRQoL levels among breast cancer survivors. Methods: This cross-sectional study included a total of 717 breast cancer survivors recruited from nine hospitals in Korea. Dietary intake was assessed using 3-day dietary records (DRs) or a validated food frequency questionnaire (FFQ). The HRQoL of the participants was assessed using the Short Form-36 (SF-36) Health Survey, which comprises eight domains. To examine the inflammatory dietary pattern, the reduced rank regression (RRR) was performed with the intake amount of each food group and the plasma levels of five inflammatory biomarkers (high-sensitivity C-reactive protein (hs-CRP), Interleukin (IL)-6, IL-8, adiponectin, and tumor necrosis factor (TNF)-α). The factor loadings were multiplied by the standardized daily intake (g) of each food group to calculate the inflammatory dietary pattern scores. The least square-means (LS-means) and 95% confidence intervals (95% CIs) of the HRQoL scores were estimated according to the quartiles of the inflammatory dietary pattern score using the general linear model (GLM). Additionally, a predicted pro-inflammatory hs-CRP score was derived using a previously developed model and its association with HRQoL was examined by using the GLM. Results: The inflammatory dietary pattern was characterized by high intakes of refined rice, noodle, seafood (excluding fish), sugar-sweetened coffee, carbonated or sugar-sweetened beverages, along with low intakes of salted vegetables and processed fish. Higher inflammatory dietary score was associated with lower scores on HRQoL mental health domain (p for trend = 0.034), physical functioning domain (p for trend = 0.017) and bodily pain domain (p for trend = 0.057). Higher predicted pro-inflammatory hs-CRP score was associated with lower scores on HRQoL physical component summary domain (p for trend = 0.001), physical functioning domain (p for trend = 0.003) and bodily pain domain (p for trend = 0.018). Conclusions: The inflammatory dietary pattern score and the predicted pro-inflammatory hs-CRP score may be inversely associated with the HRQoL levels in breast cancer survivors. Citation Format: Ji Yeong Kim, Sang-Eun Moon, Hyun Jeong Cho, Zisun Kim, Hyun Jo Youn, Jihyoung Cho, Jun Won Min, Yoo Seok Kim, So-Youn Jung, Eun Sook Lee, Young Bum Yoo, Se Kyung Lee, Seho Park, Jung Eun Lee. Associations of inflammatory dietary patterns and predicted pro-inflammatory hs-CRP scores with health-related quality of life among breast cancer survivors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 7366.