Abstract 7080: Association between atherogenic index of plasma and cancer risk: A prospective cohort study

Abstract Introduction: Cardiovascular disease (CVD) and cancer are among the leading causes of morbidity and mortality globally, with shared mechanisms and risk factors. Patients with CVD face higher risk of multiple cancer subtypes and cancer-related death. The initiation of atherosclerotic plaque formation frequently underlies CVD. Atherogenic index of plasma (AIP), a marker of plasma atherosclerosis, had proved to be a powerful biomarker of CVD. However, few studies have investigated the association between AIP and the risk of overall cancer and common site-specific cancers incidence and mortality in the general population. Methods: Participants were from the UK Biobank database, a prospective population-based cohort. The exposure variable was the AIP, which was defined as log10 (triglycerides/high-density lipoprotein cholesterol) and participants were categorized into four groups based on their AIP values. The main outcomes included the incidence and death of 20 site-specific cancers: oral, esophagus, stomach, colorectum, liver, pancreas, lung, melanoma, breast, uterus, ovary, prostate, kidney, bladder, brain, thyroid, lymphoma, myeloma, leukemia and mesothelioma cancers. Follow-up time was measured in person years from the baseline enrollment time to the date of cancer diagnosis, death, or the end of follow-up (whichever comes first). We used COX proportional hazards regression model to evaluate the association between AIP and main outcomes. Restricted cubic spline was used for further evaluating the non-linear association. Results: 401, 499 participants were included in this study after excluding baseline cancer and covariates missing, and a total of 55, 886 and 14, 457 cases of primary cancer and cancer deaths were documented during the median follow-up period of 12.6 years and 14.3 years, respectively. The correlation between AIP and overall cancer risk was not significant. For site-specific cancers, higher AIP was positively associated with lung cancer (LC), endometrial cancer (EC), leukemia and mesothelioma risk, and negatively associated with oral cancer, malignant melanoma and ovarian cancer risk. Especially, higher level of AIP was significantly correlated with higher LC risk, (for Q4-Q1, incidence: 1.19, 95% CI:1.07-1.32, P = 0.001, mortality: 1.21, 95% CI:1.07-1.37, P = 0.002). Compared to the Q1 group, the higher AIP level group (Q2-Q4) had a higher incidence risk of EC (HR range of 1.25 to 1.39, P < 0.001). Furthermore, a U-shaped association was found between AIP and colorectal cancer both in incidence (P for non-linear = 0.012) and mortality (P for non-linear 0.024). Conclusions: AIP was significantly associated with various cancers risk, especially with higher risk of LC and EC. The results suggested that daily monitoring and management of AIP levels are necessary to reduce cancer risk. Citation Format: Mengbo Xing, Zhangyan Lyu, Wenxuan Li, Yue Cong, Chao Sheng, Hongru Shen, Kexin Chen. Association between atherogenic index of plasma and cancer risk: A prospective cohort study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 7080.