Abstract 7381: Esophageal carcinoma association with chronic liver disease and cirrhosis mortality risk: A population based retrospective study

Abstract Introduction: The American Cancer Society estimates about 22, 370 new esophageal cancer (EC) cases and about 16, 130 deaths in the United States for 2024. While the rates of esophageal cancer have decreased slightly in recent years, the chronic liver disease and cirrhosis (CLD & C) mortality rates are upwardly trending. We holistically analyzed the CLD & C mortality risk in EC patients given the multiple risk factors that are common to these diseases. Methods: Using the Surveillance, Epidemiology and End-Result (SEER) Research Data, 17 registries and Multiple Primary Standardized Incidence Ratio (MP-SIR) registries, a retrospective study of patients diagnosed with esophageal cancer between 2000 and 2021 was conducted. We estimated the standardized mortality ratios (SMR) by dividing the observed chronic liver disease and cirrhosis death rates in our sample over expected dates of the general population, matched to age, gender and ethnicity. Results: Analysis of the risk based on race revealed a much higher risk of CLD & C in American Indian/Alaska Natives compared to other races. American Indian/Alaska Natives had SMR 555.37 (CI 114.53-1623.04, p < 0.05), Asian/Pacific Islanders SMR 89.56 (CI 32.87-194.94, p < 0.05), Black SMR 44.52 (CI 21.35-81.88, p < 0.05), Whites SMR 20.49 (CI 17.27-24.14, p < 0.05). Females had a higher risk of CLD & C mortality (SMR 36.46, CI 22.84-55.18, p < 0.05) compared to males (SMR 20.98, CI 17.65-24.76, p < 0.05). We also analyzed mortality risk based on staging of esophageal cancer. Localized EC SMR was 24.12 (CI 17.78-31.98, p < 0.05), Regional EC SMR 16.09 (CI 11.98-21.26, p < 0.05), Distant EC SMR 47.03 (CI 30.43-69.42, p < 0.05). Based on age, patients aged <60 years SMR 31.09 (CI 24.10-39.49, p < 0.05), patients aged 60-69 years SMR 24.71 (CI 18.99-31.61, p < 0.05) and patients aged 70+ years SMR 12.45 (CI 8.51-17.57, p < 0.05). Conclusion: These data should inform screening and preventive strategies for esophageal cancer patients. It is well known that esophageal cancer and CLD & C share multiple risk factors. American Indian/Alaska Natives was noted to have a much higher SMR compared to other races. Primary and Secondary preventive modalities must be strategized to tackle these disparities. Citation Format: Olanipekun Lanny Ntukidem, Oboseh John Ogedegbe, Sakshi Bai, Asfand Yar Cheema, Ayobami Gbenga Olafimihan, Nosakhare Paul Ilerhunmwuwa, Utkarsh Acharya, Kai He. Esophageal carcinoma association with chronic liver disease and cirrhosis mortality risk: A population based retrospective study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 7381.