Abstract 7092: The change in Asian American/Native American/Pacific Islander demographics in interventional clinical trials in Hawai'i

Abstract Asian Americans, Native Hawaiians, and Pacific Islanders (AA/NH/PI) contribute significantly to the state’s ethnic diversity. Despite their substantial presence, these groups face considerable health disparities, particularly in access to and participation in clinical trials. Furthermore, detailed accrual data based on ethnicity is missing as national datasets often aggregate AA/NH/PI populations into a single racial category. The aim of this study is to investigate change in accrual rates to interventional oncology clinical trials over time and determine the patient demographic factors that caused disparities in the trial participation. Through the Clinical Trial Management System at the University of Hawai'i Cancer Center, we collected patient enrollment data for NCI-funded interventional clinical trials (i.e., National Cancer Trials Network, NCTN and NCI Community Oncology Research Program, NCORP trials) conducted within the Hawai'i Cancer Consortium (HCC) between 2005 and 2020. The HCC is constituted by seven entities, including 2 major healthcare organizations in Hawai'i. The dataset comprised of demographic details such as biological sex, age, and race. Among 2, 341 study participants who were identified by screening, 870 were enrolled in non-therapeutic studies, while 1, 471 were involved in therapeutic trials. Nearly 50% identified as Asian American, 25% as White, and 12% as Native Hawaiian, and 3% as Pacific Islander. The remaining 10% were categorized as Black, American Indian, Multiracial, Other, or Unknown. The number of Asian American participants showed a declining trend until 2014, after which it began to recover. The number of Native Hawaiian and Pacific Islander participants has been stable over this time period. Female participation consistently exceeded male participation over the study period. The annual enrollment of all participants remained low until 2014 but steadily increased, reaching its peak in 2019. This study revealed that local AA/NH/PI accrual has a different trend from the national accrual over time. While the findings suggest that local, continuous community outreach efforts have been effective, male patient accrual remains inequitable. To address this disparity, our center is currently implementing an educational program aimed at Native Hawaiian men to help eliminate mistrust in clinical trial participation. Citation Format: Aiesha Pradhan, Jangsoon Lee, Naoto T. Ueno, Toshiaki Iwase. The change in Asian American/Native American/Pacific Islander demographics in interventional clinical trials in Hawai'i [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; Part 1 (Regular Abstracts); 2025 Apr 25-30; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2025;85(8_Suppl_1):Abstract nr 7092.